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Overview of Ganirelix Ganirelix , also known as Ganirelix acetate or Ganirest, is an injectable competitive gonadotropin-releasing hormone (GnRH) antagonist.

The following is a detailed introduction to it: Basic Information CAS Number: 129311-55-3 English Name: Ganirelix acetate Molecular Formula: C??H???ClN??O?? Molecular Weight: 1690.423 Precise Mass: 1688.884521 Storage conditions: At -20°C, in a sealed and dry environment, bioactive acetate carnations can directly compete with endogenous molecules for receptor binding, thereby causing a rapid decrease in estradiol levels.

It has significant application value in the fields of medical research and treatment, especially for the study of ovarian hyperstimulation syndrome (OHSS) . Chemical synthesis of Ganirelix (N-Ac-Nal (2) -D-Pcl-PHE-D-Pal (3) -Ser-tyR-D-HARg (Et)? -Leu-HARg (Et)? -pro-ALA - The preparation of NH? employed specific side chain protection schemes, such as salt protection (as chlorides) for L - and D-hArg (Et)?, and tert-butyl protection for serine. Amino acids were added to Nα -Boc-D-Ala-O-Resin in a specific order. After adding Ala,

Pro and Leu, acetylation was carried out with N, N' -diisopropyl carbodiimine-1-hydroxybenzotriazole (HBt) (end-terminated resin). Excess HBt (2 equivalent) is used when coupling the basic amino acids hArg(Et)? and Pal(3). After each amino acid is added, the Nα -protecting group 3 is removed using a specific procedure.

In terms of medical research, it is mainly used for the study of ovarian hyperstimulation syndrome (OHSS). In clinical treatment, it may have certain application prospects in fields such as assisted reproductive technology. However, all products displayed on this website are only for scientific research and are not edible.

They should not be used for clinical diagnosis and treatment of humans or animals