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Introduction to Somatostatin

1. Definition and Structure Somatostatin, also known as Somatostatin, is an endogenous peptide mainly composed of 14 amino acids (Somatostatin-14), and there is also a longer form with 28 amino acids (somatostatin -28). It is a neuroactive substance with the function of inhibiting the secretion of growth hormone (GH) and regulating the secretion of pituitary hormones in the human central nervous system. The chemical structure formula of Somatostatin is complex. Its molecular formula is C76H104N18O20S2 and its molecular weight is 1653.878.

2. Biological activity
Inhibitory effect: Somatostatin can inhibit the secretion of various hormones, including but not limited to growth hormone, insulin and glucagon, etc. In addition, it can also control the secretion of pituitary hormones in the central nervous system.
Anti-tumor properties: Studies have shown that Somatostatin can reduce the adhesion of sarcoma cells to blood vessels, thereby lowering the metastatic potential of these tumors. Meanwhile, it can also inhibit the chemotactic migration of monocytes.
Cardiovascular effects: Somatostatin and acetylcholine are co-stored in neuropeptides innervated by the parasympathetic nerve of the heart, directly affecting the contraction of ventricular cardiomyocytes. It can inhibit the contractile response of isoproterenol, with an IC50 value of 13 nM.

3. Application in scientific research:

Somatostatin is widely used in proteomics research and the study of cardiovascular diseases. As a neuroactive peptide, it is used in a laboratory environment to explore its effects on different physiological processes.
Clinical application: Although Somatostatin itself is not used for clinical treatment, analogues based on it have been developed for the treatment of certain types of cancer and other diseases. For example, Somatostatin Acetate has been used to study the bleeding conditions of severe acute gastric and duodenal ulcers