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Introduction to Atosiban Acetate

Atosiban Acetate, a nonapeptide compound, has the chemical name desamino-oxytocin analogue. It is mainly used as a competitive vasopressin/oxytocin receptor antagonist.

It is widely used in medical research for the study of spontaneous preterm birth and is one of the main uterine contraction inhibitors.

Chemical properties

Molecular formula: C45H71N11O14S2

Molecular weight: 994.19

CAS Number: 90779-69-4

Storage conditions: It needs to be stored in a sealed and dry container. Some suppliers recommend storage at a low temperature of 2-8℃. The validity period is usually 2 years.

Solubility: The solubility in DMSO is 100 mg/mL (94.86 mM), and ultrasonic treatment is required to ensure complete dissolution.

Biological activity and mechanism of action: Atosiban Acetate achieves the effect of inhibiting uterine contractions by inhibiting the release of IP3 mediated by oxytocin from the uterine muscle cell membrane, reducing the release of intracellular stored calcium ions and the inflow of calcium ions from the extracellular space through voltage-gated channels.

In addition, Atosiban can also inhibit the release of prostaglandin E (PGE) and prostaglandin F (PGF) from the decidua mediated by oxytocin.

Clinical application: It is mainly used to treat regular uterine contractions of more than 4 times every 30 minutes, each lasting at least 30 seconds, and accompanied by cervical dilation in pregnant women with a gestational age of 24 to 33 weeks and normal fetal heart rate, with the aim of delaying the upcoming premature birth.

Research application: Widely used in scientific research and drug development, especially in studies related to uterine contractions